Before You Continue...

A first step as you consider this study is to answer a 5-minute online questionnaire about your health and medical history. If your answers show the study might be a good fit for you, you may choose to be referred to a study clinic that you select. You will then be asked to provide your contact information for a study representative to contact you and discuss the next steps. Only the study staff can determine if you meet the study's eligibility criteria and are able to enroll in the study.

Click 'Next' to begin the questionnaire.

Question 1 of 3
Please select your age.
Question 2 of 3
Have you received 4 or 5 prior doses of an mRNA COVID-19 vaccine (made by either Pfizer & BioNTech or Moderna), with your last dose given at least 4 to 12 months ago? It does not matter whether your prior doses were made by the same or different companies to be able to participate in this study.
Question 3 of 3
Have you received a licensed flu vaccine for the current flu season that was given at least 4 months ago? You must have already received the current annual flu vaccine to participate in this study.

Sorry, you are not eligible at this time or enrollment for your age group is currently closed.

Thank you so much for your interest in this research study and for answering our questions. There may be other Pfizer research studies enrolling in your area in the future. If you would like to be notified about future research opportunities, we will collect your name, phone number, physical address and email address so that a study representative may contact you about other research studies. Your contact information will not be used for any other purposes.

The individual responses you've provided will be used by Pfizer, or our partners supporting this study, to look for areas of improvement such as revising the criteria for participation in this study. Pfizer study team members and our partners will have access to reports containing aggregated data that will not be directly linked back to you. All information is stored on servers in the United States.

So far - So good!

Please enter your information below to find a study location near you. By submitting this form, you confirm that you are at least 18 years of age (or the legal age of consent in your state if it is over 18) and that Pfizer or our partners may contact you about information related to research studies enrolling in your area. Once you select a site, the research study staff will contact you to see if you qualify to enroll.

Choose a Location
Please select a research site near you. If you don't see a site near you, select "The sites listed here are not convenient for me." and a study representative will contact you if a research site becomes available in your area.

Orange County Research Center

14351 Myford Rd, Suite B
Tustin, CA 92780
NaN Mi

Invesclinic U.S,LLC

5353 N. Federal Highway, Suite 406
Fort Lauderdale, FL 33308
NaN Mi

Meridian Research

340 Eisenhour Dr., Bld. 1500
Savannah, GA 31406
NaN Mi

DBC Research USA

18503 Pines Blvd., Suite 303
Pembroke Pines, FL 33029
NaN Mi

North Alabama Research Center New Horizons Research Group

721 West Market St., Suite B
Athens, AL 35611
NaN Mi

Main Street Physician's Care

3600 Sea Mountain Hwy., Suite C
Little River, SC 29556
NaN Mi

M3 Wake Research, Inc.

3100 Duraleigh Rd., Ste. 304
Raleigh, NC 27612
NaN Mi

The sites listed here are not convenient for me.

Sorry, you are not eligible at this time or enrollment for your age group is currently closed.

Please enter your information below if you would like to be contacted about future clinical research opportunities. By submitting this form, you confirm that you are at least 18 years of age (or the legal age of consent in your state if it is over 18) and that Pfizer or our partners may contact you about information related to research studies enrolling in your area.

First name must not be blank

Last name must not be blank

Please enter a valid phone number

Please enter a valid email

Please select a valid address

The swift delivery of the world's first COVID-19 vaccine put a spotlight on the potential of mRNA technology and has opened new doors for vaccine development. mRNA-based vaccines for a variety of diseases are now being researched, including potential new vaccines for flu.

Both COVID-19 and flu continue to be an area of critical need for public health globally. Millions of cases of illness are attributed to these two viruses each year and they can be life-threatening for many individuals. Receiving the recommended COVID-19 boosters and an annual flu vaccine is the best strategy for protecting yourself and others from serious illness.

Currently, COVID-19 boosters and the annual flu vaccine are given as separate vaccines. Advances in mRNA technology could make it possible to combine a COVID-19 booster with the annual flu vaccine into a single shot.

A combined vaccine would be more convenient and accessible for most people. This could help increase vaccination rates and provide greater protection against both of these infectious diseases.

About the Study

This study is evaluating the safety and immune response generated by an investigational mRNA COVID-19 and flu combination vaccine compared to an investigational mRNA-based flu vaccine alone, or the COVID-19 vaccine given at the same time as a licensed flu vaccine. The investigational vaccine is thought to work by activating your immune system using mRNA. There is no weakened or dead COVID-19 or flu virus in the investigational vaccine.

Your participation in this research study will not only help advance a potential combined COVID-19 and flu vaccine, but will support investigational vaccine development for other infectious diseases. So, thank you for taking the time to learn more.

Who Can Participate?

This study will include participants from two different age groups who meet the following criteria. We are currently accepting referrals who are 65 or older and invite you to complete our online questionnaire to see if you may be able to participate. Enrollment for participants 18 to 64 is now complete. If you are in this age group, you can still register to be notified about other clinical research opportunities.

18 to 64 years of age:

  • Are generally healthy or have stable chronic conditions
  • Have received exactly 3 prior doses of the Pfizer & BioNTech COVID-19 vaccine, with the last dose given 5 to 12 months ago
  • Have not received a licensed or investigational flu vaccine within the last 6 months

65 years of age or older:

  • Are generally healthy or have stable chronic conditions
  • Have received 4 or 5 prior doses of the Pfizer & BioNTech or Moderna COVID-19 vaccine, with the last dose given at least 4 to 12 months ago
  • Have already received a licensed flu vaccine for the current flu season given at least 4 months ago
There are other requirements to join this research study. A study team member will help determine if this study is right for you based on all participation criteria. You must be at least 18 years of age (or the legal age of consent in your state if it is over 18) to enroll in this study.

Be Represented

While everyone needs to be represented in vaccine clinical studies, it is especially important that these vaccine studies include people from the communities most significantly impacted by COVID-19 and flu. By choosing to volunteer, you will represent people like you - in age, sex, race, and ethnicity and from communities like yours. Involving people from all backgrounds will improve the development of this investigational vaccine for everyone. By volunteering for this vaccine study, you can make a difference.

About mRNA Vaccines

The immune system is the body's natural defense against infections. Vaccines help the immune system recognize viruses and bacteria that may invade the body in the future.

Some vaccines contain a small amount of the virus or bacteria from the disease they are designed to help prevent. The virus or bacteria has either been killed or weakened so it cannot make a person sick. Other vaccines contain only a part of the germ from the disease.

The investigational vaccine being studied is an mRNA vaccine, which does not contain any killed or weakened virus. mRNA vaccines work by telling your body to produce proteins that look just like certain parts of the virus. The immune system reacts to these proteins in a similar way to a real virus. As a result, certain immune system cells "remember" how to recognize these proteins quickly and fight the real infection if it happens in the future.

About the Study Vaccines

The mRNA COVID-flu vaccine being studied is a combination of Pfizer & BioNTech's bivalent Omicron vaccine (authorized in the US as a single booster dose in people 5 years and older) and an investigational mRNA flu vaccine. The bivalent Omicron vaccine is a combination of two vaccines, meaning it targets two strains of the COVID virus - the Omicron variant and the original COVID-19 virus. The investigational mRNA flu vaccine and licensed flu vaccine are quadrivalent vaccines, meaning they target four strains of the flu virus.

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What To Expect

injection

Study participants will receive either the investigational mRNA COVID-flu combination vaccine, an investigational mRNA flu vaccine, or the bivalent Omicron COVID vaccine and licensed flu vaccine administered as two separate vaccines. There is no placebo (inactive) vaccine being used in this study.

calendar

This research study will last about six months. Participants will have at least six study visits, including screening, vaccination, and four follow-up visits to monitor their health. Participants will also be contacted at home by telephone approximately six months after their vaccination to ask about their health.

phone

Over the course of the study, participants will need to report any changes in their health. To make this easier, they will be given an electronic diary (eDiary) to use, or they can download the secure eDiary app to their smartphone.

money

The study vaccine and study-related procedures will be provided at no cost. Participants do not need health insurance to take part. Compensation will also be provided for time and travel.

phone

Research studies are voluntary. Taking part in a research study is a personal choice. Participants may leave the study at any time and for any reason.

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